Research is the intellectual foundation of AASE Institute. The Institute conducts and supports original research at the intersection of science, entrepreneurship, innovation, commercialization, emerging technology, and investment. Its purpose is not only to study what has happened in the past, but also to develop new theories, frameworks, methods, and evidence that can help scientists, entrepreneurs, companies, and investors understand what may happen next and make better decisions. AASE Institute approaches research from both an academic and practical perspective. Academic research provides the theories, evidence, and methods needed to understand complex problems. Practical research examines how these ideas can be applied to scientific discovery, technology development, startup creation, commercialization, investment, and industry. By connecting these two sides, the Institute seeks to produce research that contributes to academic knowledge while remaining useful in the real world.

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Original Theories

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Developing original theories is one of the highest priorities of AASE Institute. Many important questions in science-driven innovation are still studied mainly by looking backward. Researchers often examine successful scientists, technologies, companies, or investments after the outcome is already known and then identify factors that may have contributed to that success. AASE Institute seeks to move beyond this approach. Its research asks whether the processes that lead to success can be understood earlier, measured more systematically, and eventually predicted.

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A major example is Predictive Success Science™, an original research framework that studies whether success can be predicted before the final outcome occurs. The program examines determinants of success, causal relationships, probability formation, predictability boundaries, predictability windows, critical thresholds, trajectories, leading indicators, and changing probabilities over time.

 

The broader goal is to develop theories that can be tested, challenged, improved, and applied across different fields rather than remaining as general ideas about why some people, technologies, or organizations succeed.

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Research Programs

 

AASE Institute develops focused research programs around major questions affecting science, entrepreneurship, and innovation. These programs may be conducted independently by the Institute or in collaboration with universities, research institutions, companies, investors, and other organizations. Major research areas include scientist entrepreneurship, research translation, technology commercialization, startup development, innovation, investment, emerging technologies, and success prediction.

Research questions may include:

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(1) Why do some scientific discoveries become successful products while others remain in laboratories?

(2) Which factors determine whether a scientist can successfully make the transition from researcher to entrepreneur?

(3) At what stage can the commercial potential of a technology be evaluated with useful accuracy?

(4) What early indicators distinguish technologies that are likely to reach the market from those that are likely to fail?

(5) How do scientific evidence, intellectual property, management, financing, regulation, competition, and market demand interact during commercialization?

(6) How should investors evaluate technologies when scientific potential is high but commercial evidence remains limited?

(7) How can emerging technologies and industries be identified before they become widely recognized?

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These questions allow the Institute to study the entire pathway from scientific discovery to economic and social impact.

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Perspective Articles

 

AASE Institute uses Perspective articles to introduce important new ideas, identify emerging research questions, challenge existing assumptions, and propose new directions for science, entrepreneurship, innovation, and investment.

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A Perspective should do more than summarize existing literature. It should present a clear argument about how a field could be understood differently, what important problem has been overlooked, or what new framework deserves further investigation. For example, Perspectives developed through the Institute may examine whether success should become a formal subject of predictive science, whether commercialization risk can be measured before product development is complete, or whether scientific entrepreneurship requires its own theoretical framework rather than being treated simply as a branch of general entrepreneurship.

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High-quality Perspectives can therefore serve an important role in establishing new research directions. They can also provide the conceptual foundation for later empirical studies, mathematical models, collaborative projects, and real-world validation.

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Review Articles

 

Review articles provide a systematic understanding of established and emerging fields relevant to the Institute's mission.

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Rather than simply collecting published studies, AASE Institute Reviews seek to identify the major findings, disagreements, gaps, methods, and unanswered questions within a field. Reviews may cover areas such as scientist entrepreneurship, academic spinouts, technology transfer, research commercialization, venture investment, innovation ecosystems, biotechnology entrepreneurship, emerging technologies, and predictive approaches to innovation.

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Reviews also help connect research communities that often operate separately. A scientist may understand a technology deeply but have limited knowledge of venture finance. An investor may understand markets but lack detailed knowledge of scientific development. A university researcher may understand discovery but have little experience with product development or commercialization. By bringing these perspectives together, Institute Reviews can provide a more complete picture of how science moves toward application.

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Empirical and Collaborative Research

 

Original theories become valuable only when they can be examined against evidence. AASE Institute therefore places strong emphasis on empirical research and real-world validation. Research may use longitudinal datasets, startup and investment databases, patent information, publication records, technology development milestones, commercialization outcomes, surveys, interviews, case studies, and other sources of evidence. Whenever possible, predictions and frameworks should be evaluated using outcomes that were not already known when the prediction was made. This is particularly important for Predictive Success Science™, where the distinction between explaining past success and predicting future success must remain clear.

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AASE Institute can also establish collaborative research networks with universities, companies, accelerators, venture funds, laboratories, and other institutions. These partnerships can provide access to expertise, datasets, case studies, and real-world environments in which new ideas can be tested.

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Research Reports

 

Not every important research question needs to be communicated only through a traditional academic paper. AASE Institute Research Reports provide another major channel for presenting findings.

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Research Reports can address timely subjects such as global technology trends, scientist entrepreneurship, commercialization success and failure, biotechnology development, venture investment, emerging industries, and changes in innovation ecosystems. These reports can combine academic evidence with industry data and practical analysis. Depending on the subject, they may include frameworks, datasets, case studies, figures, decision tools, forecasts, and recommendations. Some reports may be publicly available as part of the Institute's educational mission. Others may be developed as major annual reports, sponsored research, collaborative publications, or specialized intelligence products.

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From Research to Application

 

AASE Institute research is designed to move through a continuous process:

Question → Theory → Framework → Evidence → Validation → Publication → Application

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A new question may first lead to a theoretical paper or Perspective. The theory can then be developed into measurable variables and research hypotheses. Empirical studies can test these ideas. Results can be published and independently examined. If the evidence supports the framework, it can then be translated into practical methods, educational programs, strategic tools, or decision systems. This approach allows research to remain academically serious while creating pathways toward real-world use.

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Building an International Research Network

 

AASE Institute ultimately seeks to build an international research community around the intersection of science, entrepreneurship, innovation, commercialization, investment, and prediction.

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Scientists can contribute scientific expertise. Economists and management scholars can study organizations and markets. Mathematicians and statisticians can develop quantitative models. Data scientists can analyze complex datasets. Entrepreneurs can provide real-world experience. Companies can contribute commercialization cases. Investors can help identify the questions that matter when capital is allocated under uncertainty. By bringing these communities together, AASE Institute can address questions that no single discipline can answer alone.

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The Institute's research mission can therefore be summarized in one pathway:

Develop Original Ideas → Build Testable Theories → Generate Evidence → Publish High-Quality Research → Validate in the Real World → Translate Knowledge into Better Decisions

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Through original theories, research programs, Perspective articles, Reviews, empirical studies, collaborative research, and research reports, AASE Institute aims to create a growing body of knowledge that helps explain—and increasingly predict—how scientific ideas become innovations, companies, investments, and lasting real-world impact.

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